A comprehensive company database analysis of biological assay variability.
Drug Discov Today
; 21(8): 1213-21, 2016 08.
Article
em En
| MEDLINE
| ID: mdl-27063506
ABSTRACT
Analysis of data from various compounds measured in diverse biological assays is a central part of drug discovery research projects. However, no systematic overview of the variability in biological assays has been published and judgments on assay quality and robustness of data are often based on personal belief and experience within the drug discovery community. To address this we performed a reproducibility analysis of all biological assays at AstraZeneca between 2005 and 2014. We found an average experimental uncertainty of less than a twofold difference and no technologies or assay types had higher variability than others. This work suggests that robust data can be obtained from the most commonly applied biological assays.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Bioensaio
Idioma:
En
Revista:
Drug Discov Today
Ano de publicação:
2016
Tipo de documento:
Article