Imaging Mass Spectrometry Reveals a Decrease of Cardiolipin in the Kidney of NASH Model Mice.
Anal Sci
; 32(4): 473-6, 2016.
Article
em En
| MEDLINE
| ID: mdl-27063723
ABSTRACT
Non-alcoholic steatohepatitis (NASH) can be complicated with chronic kidney disease (CKD). In this study, changes in the distribution of biomolecules in the kidney were studied in NASH model mice with the use of imaging mass spectrometry (IMS). The mass spectra and ion images of IMS showed that the signals of cardiolipin (CL) species were decreased in the kidney cortex of the NASH mice. The decrease of CL might therefore suggest the kidney involvement of NASH.
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
1_ASSA2030
Base de dados:
MEDLINE
Assunto principal:
Cardiolipinas
/
Modelos Animais de Doenças
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Insuficiência Renal Crônica
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Hepatopatia Gordurosa não Alcoólica
/
Rim
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Anal Sci
Ano de publicação:
2016
Tipo de documento:
Article