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Clinical, imaging, and follow-up observations of patients with anti-GABAB receptor encephalitis.
Qiao, Song; Zhang, Yin-Xi; Zhang, Bi-Jun; Lu, Ru-Yi; Lai, Qi-Lun; Chen, Lin-Hui; Wu, Jiong.
Afiliação
  • Qiao S; a 1 Department of Neurology , Zhejiang Hospital , Hangzhou , China.
  • Zhang YX; b 2 Department of Neurology, Second Affiliated Hospital, School of Medicine , Zhejiang University , Hangzhou , China.
  • Zhang BJ; b 2 Department of Neurology, Second Affiliated Hospital, School of Medicine , Zhejiang University , Hangzhou , China.
  • Lu RY; b 2 Department of Neurology, Second Affiliated Hospital, School of Medicine , Zhejiang University , Hangzhou , China.
  • Lai QL; a 1 Department of Neurology , Zhejiang Hospital , Hangzhou , China.
  • Chen LH; b 2 Department of Neurology, Second Affiliated Hospital, School of Medicine , Zhejiang University , Hangzhou , China.
  • Wu J; a 1 Department of Neurology , Zhejiang Hospital , Hangzhou , China.
Int J Neurosci ; 127(5): 379-385, 2017 May.
Article em En | MEDLINE | ID: mdl-27066808
PURPOSE: Anti-gamma-aminobutyric acid B (anti-GABAB) receptor encephalitis is a newly described type of autoimmune encephalitis. We report a case series of patients diagnosed with anti-GABAB receptor encephalitis in China, focusing on their presentations, laboratory and imaging results, and outcomes, as well as the treatment strategies which were employed. METHODS: Data from patients diagnosed with anti-GABAB receptor encephalitis in the Second Affiliated Hospital, School of Medicine, Zhejiang University, from January 2014 to June 2015 were retrospectively collected and analyzed. Based on specific diagnostic criteria, seven cases were included. RESULTS: Six of the seven patients were males, and a median age at presentation of 56 years (range: 4-71 years). Seizures were the most common initial symptom, and all patients developed symptoms of typical limbic encephalitis during their disease course. Additional types of autoantibodies were identified in four patients. After presentation, three patients were found to have small cell lung cancer and one patient was eventually diagnosed with thymoma. All patients accepted first-line immune therapy, but only one chose tumor treatment. The three tumor-free patients had a good outcome, whereas those with tumors had a poor one. Finally, there were no relapses during follow-up. CONCLUSION: Anti-GABAB receptor encephalitis is a rare, unique autoimmune disease, and is often associated with tumors. It should be considered in the differential diagnosis for middle and senior-aged patients who present with predominantly limbic encephalitis symptoms. Importantly, earlier recognition of this potentially treatable condition could improve its overall prognosis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Autoanticorpos / Encéfalo / Receptores de GABA / Encefalite Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Int J Neurosci Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Autoanticorpos / Encéfalo / Receptores de GABA / Encefalite Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Int J Neurosci Ano de publicação: 2017 Tipo de documento: Article