The Crabtree and Warburg effects: Do metabolite-induced regulations participate in their induction?
Biochim Biophys Acta
; 1857(8): 1139-1146, 2016 Aug.
Article
em En
| MEDLINE
| ID: mdl-27066942
ABSTRACT
The Crabtree and Warburg effects are two well-known deviations of cell energy metabolism that will be described herein. A number of hypotheses have been formulated regarding the molecular mechanisms leading to these cellular energy metabolism deviations. In this review, we will focus on the emerging notion that metabolite-induced regulations participate in the induction of these effects. All throughout this review, it should be kept in mind that no regulatory mechanism is exclusive and that it may vary in cancer cells owing to different cell types or oncogenic background. This article is part of a Special Issue entitled 'EBEC 2016 19th European Bioenergetics Conference, Riva del Garda, Italy, July 2-6, 2016', edited by Prof. Paolo Bernardi.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fosforilação Oxidativa
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Oxigênio
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Glucose
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Glicólise
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Neoplasias
Limite:
Humans
Idioma:
En
Revista:
Biochim Biophys Acta
Ano de publicação:
2016
Tipo de documento:
Article