Estrogen receptors alpha and beta in bone.
Bone
; 87: 130-5, 2016 06.
Article
em En
| MEDLINE
| ID: mdl-27072516
ABSTRACT
Estrogens are important for bone metabolism via a variety of mechanisms in osteoblasts, osteocytes, osteoclasts, immune cells and other cells to maintain bone mineral density. Estrogens bind to estrogen receptor alpha (ERα) and ERß, and the roles of each of these receptors are beginning to be elucidated through whole body and tissue-specific knockouts of the receptors. In vitro and in vivo experiments have shown that ERα and ERß antagonize each other in bone and in other tissues. This review will highlight the role of these receptors in bone, with particular emphasis on their antagonism.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Osso e Ossos
/
Receptor alfa de Estrogênio
/
Receptor beta de Estrogênio
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Bone
Ano de publicação:
2016
Tipo de documento:
Article