The diversity-generating benefits of a prokaryotic adaptive immune system.
Nature
; 532(7599): 385-8, 2016 Apr 21.
Article
em En
| MEDLINE
| ID: mdl-27074511
Prokaryotic CRISPR-Cas adaptive immune systems insert spacers derived from viruses and other parasitic DNA elements into CRISPR loci to provide sequence-specific immunity. This frequently results in high within-population spacer diversity, but it is unclear if and why this is important. Here we show that, as a result of this spacer diversity, viruses can no longer evolve to overcome CRISPR-Cas by point mutation, which results in rapid virus extinction. This effect arises from synergy between spacer diversity and the high specificity of infection, which greatly increases overall population resistance. We propose that the resulting short-lived nature of CRISPR-dependent bacteria-virus coevolution has provided strong selection for the evolution of sophisticated virus-encoded anti-CRISPR mechanisms.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pseudomonas aeruginosa
/
Evolução Biológica
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Sistemas CRISPR-Cas
Idioma:
En
Revista:
Nature
Ano de publicação:
2016
Tipo de documento:
Article