Folic Acid Supplementation in Postpolypectomy Patients in a Randomized Controlled Trial Increases Tissue Folate Concentrations and Reduces Aberrant DNA Biomarkers in Colonic Tissues Adjacent to the Former Polyp Site.

O'Reilly, Sharleen L; McGlynn, Angela P; McNulty, Helene; Reynolds, John; Wasson, Gillian R; Molloy, Anne M; Strain, J J; Weir, Donald G; Ward, Mary; McKerr, George; Scott, John M; Downes, C Stephen

O'Reilly, Sharleen L; McGlynn, Angela P; McNulty, Helene; Reynolds, John; Wasson, Gillian R; Molloy, Anne M; Strain, J J; Weir, Donald G; Ward, Mary; McKerr, George; Scott, John M; Downes, C Stephen.

Afiliação

O'Reilly SL; Departments of Biochemistry and Immunology and.
McGlynn AP; Northern Ireland Centre for Food & Health (NICHE), School of Biomedical Sciences, University of Ulster, Coleraine, Northern Ireland; and.
McNulty H; Northern Ireland Centre for Food & Health (NICHE), School of Biomedical Sciences, University of Ulster, Coleraine, Northern Ireland; and.
Reynolds J; Faculty of Health, Deakin University, Burwood, Australia.
Wasson GR; Northern Ireland Centre for Food & Health (NICHE), School of Biomedical Sciences, University of Ulster, Coleraine, Northern Ireland; and.
Molloy AM; Clinical Medicine, School of Medicine, Trinity College, Dublin, Ireland;
Strain JJ; Northern Ireland Centre for Food & Health (NICHE), School of Biomedical Sciences, University of Ulster, Coleraine, Northern Ireland; and.
Weir DG; Clinical Medicine, School of Medicine, Trinity College, Dublin, Ireland;
Ward M; Northern Ireland Centre for Food & Health (NICHE), School of Biomedical Sciences, University of Ulster, Coleraine, Northern Ireland; and.
McKerr G; Northern Ireland Centre for Food & Health (NICHE), School of Biomedical Sciences, University of Ulster, Coleraine, Northern Ireland; and.
Scott JM; Departments of Biochemistry and Immunology and.
Downes CS; Northern Ireland Centre for Food & Health (NICHE), School of Biomedical Sciences, University of Ulster, Coleraine, Northern Ireland; and cs.downes@ulster.ac.uk.

J Nutr ; 146(5): 933-9, 2016 05.

Article em En | MEDLINE | ID: mdl-27075913

Assuntos

Pólipos Adenomatosos/genética; Colo/efeitos dos fármacos; Neoplasias do Colo/genética; Dano ao DNA/efeitos dos fármacos; Suplementos Nutricionais; Deficiência de Ácido Fólico/complicações; Ácido Fólico/uso terapêutico; Pólipos Adenomatosos/etiologia; Pólipos Adenomatosos/metabolismo; Idoso; Biomarcadores/metabolismo; Índice de Massa Corporal; Colo/metabolismo; Colo/patologia; Neoplasias do Colo/etiologia; Neoplasias do Colo/metabolismo; Colonoscopia; Ensaio Cometa; DNA/metabolismo; Metilação de DNA/efeitos dos fármacos; Feminino; Ácido Fólico/sangue; Ácido Fólico/metabolismo; Ácido Fólico/farmacologia; Deficiência de Ácido Fólico/metabolismo; Deficiência de Ácido Fólico/prevenção & controle; Humanos; Mucosa Intestinal/efeitos dos fármacos; Mucosa Intestinal/metabolismo; Mucosa Intestinal/patologia; Masculino; Pessoa de Meia-Idade; Obesidade/complicações; Pólipos; Uracila/metabolismo; Complexo Vitamínico B/farmacologia

Palavras-chave

DNA methylation; colon cancer; colonocyte; field cancerization; folate; uracil misincorporation

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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 1_ASSA2030 / 2_ODS3 Base de dados: MEDLINE Assunto principal: Dano ao DNA / Colo / Neoplasias do Colo / Pólipos Adenomatosos / Suplementos Nutricionais / Ácido Fólico / Deficiência de Ácido Fólico Tipo de estudo: Clinical_trials / Etiology_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Nutr Ano de publicação: 2016 Tipo de documento: Article

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