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Neurotoxocariasis: a systematic literature review.
Deshayes, S; Bonhomme, J; de La Blanchardière, Arnaud.
Afiliação
  • Deshayes S; Department of Internal Medicine, CHU de Caen, Caen, 14000, France.
  • Bonhomme J; Department of Microbiology, CHU de Caen, Caen, 14000, France.
  • de La Blanchardière A; Department of Infectious Diseases, CHU de Caen, Caen, 14000, France. delablanchardiere-a@chu-caen.fr.
Infection ; 44(5): 565-74, 2016 Oct.
Article em En | MEDLINE | ID: mdl-27084369
ABSTRACT

PURPOSE:

Toxocariasis is a widespread zoonosis, which may result in central nervous system injury.

METHODS:

We conducted a systematic literature review in MEDLINE, SciELO, ScienceDirect and Google Scholar up to April 2015 using a combination of the following search terms "neurotoxocariasis" or "neurotoxocarosis", "toxocariasis" or "toxocarosis" and "cerebral" or "neurologic".

RESULTS:

One hundred cases of neurotoxocariasis were identified in literature. The majority of patients were male (58 %), with a median age of 42 years. The predominant clinical pictures were myelitis (60 %), encephalitis (47 %) and/or meningitis (29 %). Fever was inconstant (23 %). The suspected mode of transmission, mentioned in only 49 % of cases, was mainly contact with dogs and/or cats (67 %) and ingestion of contaminated food (31 %). Diagnostic imaging examinations found hypodense lesions in cerebral scanner sequences and hyperintense lesions in cerebral MRI T2-weighted sequences in 65 and 57 % of encephalitis cases respectively, and in 92 % of myelitis cases in medullary MRI T2-weighted sequences. The detection of antibodies against Toxocara spp. was almost constant in blood and cerebrospinal fluid (CSF), 99 and 93 %, respectively. The two most commonly used drugs were corticosteroids (72 %) and/or albendazole (68 %) for a period of at least 3 weeks, which often needed to be repeated. Despite a low mortality rate (6 %), complete remission was observed in only 40 % of cases.

CONCLUSIONS:

Neurotoxocariasis, a completely preventable zoonosis, could lead to severe sequelae failing prompt diagnosis. A compatible clinical picture, presence of risk factors, blood eosinophilia and high titers of antibodies against Toxocara spp. in CSF should alert physicians.
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 3_ND Base de dados: MEDLINE Assunto principal: Toxocaríase / Doenças do Sistema Nervoso Tipo de estudo: Diagnostic_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Female / Humans / Male Idioma: En Revista: Infection Ano de publicação: 2016 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 3_ND Base de dados: MEDLINE Assunto principal: Toxocaríase / Doenças do Sistema Nervoso Tipo de estudo: Diagnostic_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Female / Humans / Male Idioma: En Revista: Infection Ano de publicação: 2016 Tipo de documento: Article