Exercise-induced neuroprotective effects on neurodegenerative diseases: the key role of trophic factors.
Expert Rev Neurother
; 16(6): 723-34, 2016 06.
Article
em En
| MEDLINE
| ID: mdl-27086703
ABSTRACT
Age-related neurodegenerative disorders, like Alzheimer's or Parkinson's disease, are becoming a major issue to public health care. Currently, there is no effective pharmacological treatment to address cognitive impairment in these patients. Here, we aim to explore the role of exercise-induced trophic factor enhancement in the prevention or delay of cognitive decline in patients with neurodegenerative diseases. There is a significant amount of evidence from animal and human studies that links neurodegenerative related cognitive deficits with changes on brain and peripheral trophic factor levels. Several trials with elderly individuals and patients with neurodegenerative diseases report exercise induced cognitive improvements and changes on trophic factor levels including BDNF, IGF-I, among others. Further studies with healthy aging and clinical populations are needed to understand how diverse exercise interventions produce different variations in trophic factor signaling. Genetic profiles and potential confounders regarding trophic factors should also be addressed in future trials.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Exercício Físico
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Transdução de Sinais
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Fármacos Neuroprotetores
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Doenças Neurodegenerativas
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Fatores de Crescimento Neural
Limite:
Animals
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Humans
Idioma:
En
Revista:
Expert Rev Neurother
Ano de publicação:
2016
Tipo de documento:
Article