Provocative stimulation of the hypothalamic-pituitary-testicular axis in men with spinal cord injury.
Spinal Cord
; 54(11): 961-966, 2016 Nov.
Article
em En
| MEDLINE
| ID: mdl-27112842
ABSTRACT
STUDY DESIGN:
Prospective study.OBJECTIVE:
To determine the integrity of the hypothalamic-pituitary-testicular axis in healthy men with spinal cord injury (SCI).METHODS:
Thirty healthy men with chronic SCI (37±10 years) and thirty-eight able-bodied (AB) controls (36±10 years) participated. Gonadotropin-releasing hormone (GnRH; 100 µg IV) was administered to determine gonadotropin release, and human chorionic gonadotropin (hCG; 4000 IU IM) was administered to determine testosterone (T) secretion. Responses to stimulation were categorized as 'responder' or 'non-responder' by clinical criteria. Single factor ANOVA with repeated measures was performed to identify group differences.RESULTS:
The proportion of responders to pituitary GnRH stimulation was similar in the SCI group (22 subjects (73%) for the follicular-stimulating hormone (FSH) and 23 subjects (76%) for the luteinizing hormone (LH) to that of the AB group. The SCI-responder group had an increased FSH response after stimulation compared with the AB-responder group (P<0.05). The SCI-responder group had a greater LH area under the curve to GnRH stimulation than the AB-responder group (P=0.06). The peak FSH response was at 60 min and the peak LH response at 30 min, regardless of group designation. All groups had similar increases in serum T concentration to hCG stimulation.CONCLUSIONS:
The pituitary response to stimulation in healthy men with SCI revealed an augmented FSH response; LH response only trended higher. The testicular response to provocative stimulation was similar in hypogonadal and eugondal subjects and in GnRH responders and non-responders. These findings suggest a lack of hypothalamic drive of pituitary gonadotropin release in healthy people with chronic SCI.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Traumatismos da Medula Espinal
/
Testosterona
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Hormônio Luteinizante
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Hormônio Liberador de Gonadotropina
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Hormônio Foliculoestimulante
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Gonadotropina Coriônica
Tipo de estudo:
Clinical_trials
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Observational_studies
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Prognostic_studies
Limite:
Adult
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Spinal Cord
Ano de publicação:
2016
Tipo de documento:
Article