ER stress inducer tunicamycin suppresses the self-renewal of glioma-initiating cell partly through inhibiting Sox2 translation.

Xing, Yang; Ge, Yuqing; Liu, Chanjuan; Zhang, Xiaobiao; Jiang, Jianhai; Wei, Yuanyan

Xing, Yang; Ge, Yuqing; Liu, Chanjuan; Zhang, Xiaobiao; Jiang, Jianhai; Wei, Yuanyan.

Afiliação

Xing Y; Key Laboratory of Glycoconjuates Research, Ministry of Public Health, Department of Biochemistry and Molecular Biology, Shanghai Medical College of Fudan University, Shanghai, People's Republic of China.
Ge Y; Key Laboratory of Glycoconjuates Research, Ministry of Public Health, Department of Biochemistry and Molecular Biology, Shanghai Medical College of Fudan University, Shanghai, People's Republic of China.
Liu C; Key Laboratory of Glycoconjuates Research, Ministry of Public Health, Department of Biochemistry and Molecular Biology, Shanghai Medical College of Fudan University, Shanghai, People's Republic of China.
Zhang X; Division of Neurosurgery, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China.
Jiang J; Key Laboratory of Glycoconjuates Research, Ministry of Public Health, Department of Biochemistry and Molecular Biology, Shanghai Medical College of Fudan University, Shanghai, People's Republic of China.
Wei Y; Key Laboratory of Glycoconjuates Research, Ministry of Public Health, Department of Biochemistry and Molecular Biology, Shanghai Medical College of Fudan University, Shanghai, People's Republic of China.

Oncotarget ; 7(24): 36395-36406, 2016 Jun 14.

Article em En | MEDLINE | ID: mdl-27119230

Assuntos

Autorrenovação Celular/efeitos dos fármacos; Glioma/tratamento farmacológico; Células-Tronco Neoplásicas/efeitos dos fármacos; Fatores de Transcrição SOXB1/genética; Tunicamicina/farmacologia; Ensaios Antitumorais Modelo de Xenoenxerto; Animais; Western Blotting; Autorrenovação Celular/genética; Estresse do Retículo Endoplasmático/efeitos dos fármacos; Glioma/genética; Glioma/metabolismo; Humanos; Camundongos Nus; Células-Tronco Neoplásicas/metabolismo; Biossíntese de Proteínas/efeitos dos fármacos; Reação em Cadeia da Polimerase Via Transcriptase Reversa; Fatores de Transcrição SOXB1/metabolismo; Carga Tumoral/efeitos dos fármacos; Carga Tumoral/genética; Células Tumorais Cultivadas

Palavras-chave

Sox2; glioma-initiating cell; self-renewal; tunicamycin

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células-Tronco Neoplásicas / Tunicamicina / Ensaios Antitumorais Modelo de Xenoenxerto / Fatores de Transcrição SOXB1 / Autorrenovação Celular / Glioma Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Oncotarget Ano de publicação: 2016 Tipo de documento: Article

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