In vitro fertilization (IVF) outcome in women in overt menopause attempting to induce follicular maturation by follicle stimulating hormone (FSH) receptor down-regulation.
Clin Exp Obstet Gynecol
; 43(2): 181-3, 2016.
Article
em En
| MEDLINE
| ID: mdl-27132404
ABSTRACT
PURPOSE:
To determine the frequency of ovulation induction, obtaining oocytes leading to embryos, and pregnancy rates per embryo transfer in women with premature menopause. MATERIALS ANDMETHODS:
Prospective observational study of women hoping to have in vitro fertilization-embryo transfer (IVF-ET) with their own oocytes despite being in menopause. Ethinyl estradiol was used to lower follicle stimulation hormone (FSH) and restore sensitivity of follicles to mild FSH stimulation.RESULTS:
Three of five women had a live baby. Only one woman failed to induce ovulation and thus failed to have an embryo to transfer. One woman conceived two times and delivered a live healthy baby twice. The live delivered pregnancy rate per transfer was 20% (4/20) with generally one or occasionally two embryos transferred. The pregnancy rate per retrieval was 9.3% (4/43).CONCLUSIONS:
These data can help other women in this circumstance to decide on IVF with their own eggs or switch to donor eggs.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Menopausa Precoce
/
Fertilização in vitro
/
Insuficiência Ovariana Primária
/
Taxa de Gravidez
/
Estrogênios
/
Etinilestradiol
/
Hormônio Foliculoestimulante
Tipo de estudo:
Observational_studies
Limite:
Adult
/
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Clin Exp Obstet Gynecol
Ano de publicação:
2016
Tipo de documento:
Article