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Generation of Human Liver Chimeric Mice for the Study of Human Hepatotropic Pathogens.
von Schaewen, Markus; Hrebikova, Gabriela; Ploss, Alexander.
Afiliação
  • von Schaewen M; Department of Molecular Biology, Princeton University, 110 Lewis Thomas Laboratory, Washington Road, Princeton, NJ, 08544, USA.
  • Hrebikova G; Department of Molecular Biology, Princeton University, 110 Lewis Thomas Laboratory, Washington Road, Princeton, NJ, 08544, USA.
  • Ploss A; Department of Molecular Biology, Princeton University, 110 Lewis Thomas Laboratory, Washington Road, Princeton, NJ, 08544, USA. aploss@princeton.edu.
Methods Mol Biol ; 1438: 79-101, 2016.
Article em En | MEDLINE | ID: mdl-27150085
Human liver chimeric mice have become valuable tools for the study of human hepatotropic pathogens and for the investigation of metabolism and pharmacokinetics of novel drugs. The evolution of the underlying mouse models has been rapid in the past years. The diverse fields of applications of those model systems and their technical challenges will be discussed in this chapter.
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 3_ND Base de dados: MEDLINE Assunto principal: Quimeras de Transplante / Hepatócitos / Fígado Limite: Animals / Humans Idioma: En Revista: Methods Mol Biol Ano de publicação: 2016 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 3_ND Base de dados: MEDLINE Assunto principal: Quimeras de Transplante / Hepatócitos / Fígado Limite: Animals / Humans Idioma: En Revista: Methods Mol Biol Ano de publicação: 2016 Tipo de documento: Article