Previously reported PDE3A-SLCO1C1 genetic variant does not correlate with anti-TNF response in a large UK rheumatoid arthritis cohort.
Pharmacogenomics
; 17(7): 715-20, 2016 05.
Article
em En
| MEDLINE
| ID: mdl-27180831
ABSTRACT
AIM:
A genetic variant has recently reached genome-wide significance for association with TNF-inhibitor response in rheumatoid arthritis patients. Here we undertake a replication study in a UK Caucasian population to test for association with TNF-inhibitor response. MATERIALS &METHODS:
The genetic variant, rs3794271, located within the PDE3A-SLCO1C1 locus was analyzed for correlation with treatment response using both the EULAR classification criteria and absolute change in (Δ)DAS28 scores as outcome measures.RESULTS:
Genotype data were available from 1750 TNF-inhibitor treated individuals. However, no evidence for association was observed (EULAR p = 0.91 and ΔDAS28 p = 0.93). Furthermore, no significant associations were observed upon stratification by the anti-TNF received (p > 0.05).CONCLUSION:
In the largest replication cohort conducted to date, no evidence for association was observed.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Artrite Reumatoide
/
Fator de Necrose Tumoral alfa
/
Antirreumáticos
/
Transportadores de Ânions Orgânicos
/
Nucleotídeo Cíclico Fosfodiesterase do Tipo 3
/
Variantes Farmacogenômicos
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Europa
Idioma:
En
Revista:
Pharmacogenomics
Ano de publicação:
2016
Tipo de documento:
Article