[Study of cardiovascular morbidity in nurses exposed to cytostatic drugs: Multivaried approach analysis]. / Étude de la morbidité cardiovasculaire chez les infirmiers exposés aux cytostatiques : approche par l'analyse multivariée.

ABSTRACT

OBJECTIVE: To investigate the relationship between cardiovascular morbidity and exposure to cytostatic drugs. MATERIALS AND METHODS: A descriptive analytical study was conducted with 74 nurses exposed to cytostatic drugs in oncology and 215 unexposed. A medical questionnaire was applied. Exposure to cytostatic drugs was estimated by the exposure time and the index of cytostatic contact (ICC). The statistical tests used are relative risk, odds ratio, multivariate analysis: descriptive (ACM) and predictive (AIC system). RESULTS: It is a young population; the average age is 42±9.9years with a female predominance (81%). The average length was 18.4±11.11years. The average of the ICC ranged from 0.60 to 12.6 with a highly significant difference. For morbidity, there was no difference for most cardiovascular disease (RR, 1.03; 95% CI [0.59; 1.82]) outside of hypertension and venous thrombosis. ACM objectified separation between the terms and the comments of the two groups for HTA. The interpretation of results at alpha=0.05 showed an association with cardiovascular disease. The study of the association between cardiovascular morbidity and exposure to cytostatic objectified association with seniority and the ICC with a statistically significant difference (P=0.01). CONCLUSION: Multivariate analysis helped to eliminate confounding factors and retain the ICC and length of exposure to cytostatic in the onset of cardiovascular morbidity.