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The cell wall component lipoteichoic acid of Staphylococcus aureus induces chemokine gene expression in bovine mammary epithelial cells.
Kiku, Yoshio; Nagasawa, Yuya; Tanabe, Fuyuko; Sugawara, Kazue; Watanabe, Atsushi; Hata, Eiji; Ozawa, Tomomi; Nakajima, Kei-Ichi; Arai, Toshiro; Hayashi, Tomohito.
Afiliação
  • Kiku Y; Hokkaido Research Station, National Institute of Animal Health, NARO, Sapporo, Hokkaido 062-0045, Japan.
J Vet Med Sci ; 78(9): 1505-1510, 2016 Oct 01.
Article em En | MEDLINE | ID: mdl-27211287
ABSTRACT
Staphylococcus aureus (SA) is a major cause of bovine mastitis, but its pathogenic mechanism remains poorly understood. To evaluate the role of lipoteichoic acid (LTA) in the immune or inflammatory response of SA mastitis, we investigated the gene expression profile in bovine mammary epithelial cells stimulated with LTA alone or with formalin-killed SA (FKSA) using cap analysis of gene expression. Seven common differentially expressed genes related to immune or inflammatory mediators were up-regulated under both LTA and FKSA stimulations. Three of these genes encode chemokines (IL-8, CXCL6 and CCL2) functioning as chemoattractant molecules for neutrophils and macrophages. These results suggest that the initial inflammatory response of SA infection in mammary gland may be related with LTA induced chemokine genes.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácidos Teicoicos / Lipopolissacarídeos / Quimiocinas / Glândulas Mamárias Animais Limite: Animals Idioma: En Revista: J Vet Med Sci Ano de publicação: 2016 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácidos Teicoicos / Lipopolissacarídeos / Quimiocinas / Glândulas Mamárias Animais Limite: Animals Idioma: En Revista: J Vet Med Sci Ano de publicação: 2016 Tipo de documento: Article