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Combined metabolomics and proteomics reveals hypoxia as a cause of lower productivity on scale-up to a 5000-liter CHO bioprocess.
Gao, Yuanwei; Ray, Somak; Dai, Shujia; Ivanov, Alexander R; Abu-Absi, Nicholas R; Lewis, Amanda M; Huang, Zhuangrong; Xing, Zizhuo; Borys, Michael C; Li, Zheng Jian; Karger, Barry L.
Afiliação
  • Gao Y; Barnett Institute and Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA, USA.
  • Ray S; Barnett Institute and Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA, USA.
  • Dai S; Barnett Institute and Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA, USA.
  • Ivanov AR; Barnett Institute and Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA, USA.
  • Abu-Absi NR; Biologics Development, Global Manufacturing and Supply, Bristol-Myers Squibb, 38 Jackson Road, Devens, MA, USA.
  • Lewis AM; Biologics Development, Global Manufacturing and Supply, Bristol-Myers Squibb, 38 Jackson Road, Devens, MA, USA.
  • Huang Z; Biologics Development, Global Manufacturing and Supply, Bristol-Myers Squibb, 38 Jackson Road, Devens, MA, USA.
  • Xing Z; Biologics Development, Global Manufacturing and Supply, Bristol-Myers Squibb, 38 Jackson Road, Devens, MA, USA.
  • Borys MC; Biologics Development, Global Manufacturing and Supply, Bristol-Myers Squibb, 38 Jackson Road, Devens, MA, USA.
  • Li ZJ; Biologics Development, Global Manufacturing and Supply, Bristol-Myers Squibb, 38 Jackson Road, Devens, MA, USA.
  • Karger BL; Barnett Institute and Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA, USA. b.karger@neu.edu.
Biotechnol J ; 11(9): 1190-200, 2016 Sep.
Article em En | MEDLINE | ID: mdl-27213298
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fibronectinas / Espécies Reativas de Oxigênio / Proteômica / Metabolômica / Técnicas de Cultura Celular por Lotes Limite: Animals / Humans Idioma: En Revista: Biotechnol J Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fibronectinas / Espécies Reativas de Oxigênio / Proteômica / Metabolômica / Técnicas de Cultura Celular por Lotes Limite: Animals / Humans Idioma: En Revista: Biotechnol J Ano de publicação: 2016 Tipo de documento: Article