[The relationship of vitamin D receptor gene and blood lead: a meta-analysis].
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
; 34(3): 206-9, 2016 Mar 20.
Article
em Zh
| MEDLINE
| ID: mdl-27220442
ABSTRACT
OBJECTIVE:
The correlation of vitamin D receptor (VDR) gene polymorphism and blood lead level had been in doult, which allowed us to write this article.METHODS:
Relevant studies about the blood lead and VDR B/b gene polymorphism which published from 1979-2015, were searched in multiple bibliographic databases, such as CNKI, Wanfang Database, PUBMED. Of the ten references selceted, three were divided into two groups which were classified as different researches, so there were thirteen studies in the meta-analysis. According to the level of blood lead, the studies were analyzed by three groups normal group, low dose grou and high dose group. The analysis was performed by stata 12.0 software.RESULTS:
The blood lead level of VDR B/b genotype was significantly difference in all the three groups (P<0.05) , but there were apparent heterogeneity between normal group and low dose group (P<0.05, I(2)=84.2%; P<0.05, I(2)=88.9%) , except the high dose group (P>0.05, I(2)=12.7%) ; after adjusted, all showed no heterogeneity, and the results were still the same.CONCLUSION:
The genotype of VDR may be correlated with blood lead, and the levels of blood lead varied with different genetypes.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Receptores de Calcitriol
Tipo de estudo:
Systematic_reviews
Limite:
Humans
Idioma:
Zh
Revista:
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
Ano de publicação:
2016
Tipo de documento:
Article