Comparative effects of ketoconazole on rat, dog and human testicular steroidogenesis.
J Enzyme Inhib
; 2(4): 261-8, 1989.
Article
em En
| MEDLINE
| ID: mdl-2723773
ABSTRACT
Ketoconazole is an antifungal azole derivative which also inhibits the cytochrome P-450(17)alpha, catalyzing the conversion of progestins into androgens. The effects of ketoconazole on human, dog and rat testosterone biosynthesis were compared using short term incubations of dispersed testicular cells. The results showed that ketoconazole inhibited androgen biosynthesis at lower concentrations in dispersed human testicular cells (IC50 0.08 mumol/l) than in canine (IC50 0.1 mumol/l) and rat cells (IC50 greater than or equal to 0.2 mumol/l). Furthermore, they demonstrated that ketoconazole first inhibited the 17,20-lyase activity and then the 17-hydroxylation in rat and dog cells whereas only the 17-hydroxylation was affected in human cells.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Testículo
/
Androgênios
/
Cetoconazol
Limite:
Aged
/
Animals
/
Humans
/
Male
Idioma:
En
Revista:
J Enzyme Inhib
Ano de publicação:
1989
Tipo de documento:
Article