A-Raf and C-Raf differentially regulate mechanobiological response of osteoblasts to guide mechanical stress-induced differentiation.

Zhang, Qi; Matsui, Hiroyuki; Horiuchi, Hisanori; Liang, Xing; Sasaki, Keiichi

Zhang, Qi; Matsui, Hiroyuki; Horiuchi, Hisanori; Liang, Xing; Sasaki, Keiichi.

Afiliação

Zhang Q; Department of Oral Implantology, State Key Laboratory of Oral Diseases, West China College of Stomatology, Sichuan University, Chengdu, Sichuan, China; Department of Advanced Prosthetic Dentistry, Graduate School of Dentistry, Tohoku University, Sendai, Miyagi, Japan.
Matsui H; Department of Advanced Prosthetic Dentistry, Graduate School of Dentistry, Tohoku University, Sendai, Miyagi, Japan; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan. Electronic address: jaymzhetfield@dent.tohoku.ac.jp.
Horiuchi H; Department of Molecular and Cellular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Miyagi, Japan; Department of Oral Cancer Therapeutics, Graduate School of Dentistry, Tohoku University, Sendai, Miyagi, Japan.
Liang X; Department of Oral Implantology, State Key Laboratory of Oral Diseases, West China College of Stomatology, Sichuan University, Chengdu, Sichuan, China.
Sasaki K; Department of Advanced Prosthetic Dentistry, Graduate School of Dentistry, Tohoku University, Sendai, Miyagi, Japan.

Biochem Biophys Res Commun ; 476(4): 438-444, 2016 08 05.

Article em En | MEDLINE | ID: mdl-27240957

Assuntos

Osteoblastos/citologia; Proteínas Proto-Oncogênicas A-raf/metabolismo; Proteínas Proto-Oncogênicas c-raf/metabolismo; Animais; Diferenciação Celular/fisiologia; Linhagem Celular; Sobrevivência Celular; MAP Quinase Quinase Quinases/genética; MAP Quinase Quinase Quinases/metabolismo; Camundongos; Proteínas Quinases Ativadas por Mitógeno/genética; Proteínas Quinases Ativadas por Mitógeno/metabolismo; Osteoblastos/fisiologia; Proteínas Proto-Oncogênicas A-raf/genética; Proteínas Proto-Oncogênicas c-raf/genética; Interferência de RNA; Receptores Purinérgicos P2X7/genética; Receptores Purinérgicos P2X7/metabolismo; Estresse Mecânico

Palavras-chave

A-Raf; Bone mechanobiology; C-Raf; ERK; Osteoblast differentiation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteoblastos / Proteínas Proto-Oncogênicas c-raf / Proteínas Proto-Oncogênicas A-raf Limite: Animals Idioma: En Revista: Biochem Biophys Res Commun Ano de publicação: 2016 Tipo de documento: Article

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