Regeneration and rewiring of rodent olfactory sensory neurons.
Exp Neurol
; 287(Pt 3): 395-408, 2017 Jan.
Article
em En
| MEDLINE
| ID: mdl-27264358
ABSTRACT
The olfactory sensory neurons are the only neurons in the mammalian nervous system that not only regenerate naturally and in response to injury, but also project to specific targets in the brain. The stem cells in the olfactory epithelium commit to both neuronal and non-neuronal lineages depending on the environmental conditions. They provide a continuous supply of new neurons. A newly generated neuron must express a specific odorant receptor gene and project to a central target consist of axons expressing the same receptor type. Recent studies have provided insights into this highly regulated, complex process. However, the molecular mechanisms that determine the regenerative capacity of stem cells, and the ability of newly generated neurons in directing their axons toward specific targets, remain elusive. Here we review progresses and controversies in the field and offer testable models.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Condutos Olfatórios
/
Neurônios Receptores Olfatórios
/
Recuperação de Função Fisiológica
/
Traumatismos do Nervo Olfatório
/
Regeneração Nervosa
Limite:
Animals
Idioma:
En
Revista:
Exp Neurol
Ano de publicação:
2017
Tipo de documento:
Article