[Breast metastases from lung cancers with the EGFR mutation]. / Métastases mammaires des cancers bronchopulmonaires avec mutation de l'EGFR.
Rev Mal Respir
; 34(1): 61-65, 2017 Jan.
Article
em Fr
| MEDLINE
| ID: mdl-27282326
ABSTRACT
INTRODUCTION:
The breast is a rare site for metastases from lung cancers. Their occurrence in patients with adenocarcinoma which has the EGFR mutation is exceptional. In this context, it is sometimes difficult to differentiate a second primary breast cancer from a breast metastasis. OBSERVATIONS We report the cases of two patients who developed breast metastases from lung adenocarcinoma that was TTF1 positive with a deletion of exon 19 of the EGFR gene. A non-smoking woman of Asian origin, presented with a solitary breast metastasis 29 months after being established on first-line chemotherapy. The second case was a Caucasian patient who was an active smoker presented with tumor progression with multiple metastases including involvement of both breasts 10 months after the start of treatment with a tyrosine kinase inhibitor. In both, tumor cells from the breast showed positive immunostaining for TTF1 and genotyping detected the presence of the deletion of exon 19 of the EGFR gene.CONCLUSION:
In patients with lung adenocarcinoma and EGFR mutation, immunohistochemical examination, including TTF1 and genotyping of synchronous breast tumour, is needed to confirm its metastatic nature and to guide treatment.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
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Adenocarcinoma
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Receptores ErbB
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Neoplasias Pulmonares
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Mutação
Limite:
Aged
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Female
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Humans
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Middle aged
Idioma:
Fr
Revista:
Rev Mal Respir
Ano de publicação:
2017
Tipo de documento:
Article