A case report of cutaneous polyarteritis nodosa in siblings.
Mod Rheumatol
; 28(6): 1049-1052, 2018 Nov.
Article
em En
| MEDLINE
| ID: mdl-27299947
ABSTRACT
Cutaneous polyarteritis nodosa (CPAN) is characterized by a necrotizing vasculitis of small and medium-sized arteries in the skin, which can be associated with fever, arthralgia, myalgia, and neuropathy, but, unlike polyarteritis nodosa (PAN), there is no visceral involvement. CPAN is rare in childhood. We report two siblings who developed CPAN during childhood. Interestingly, both had Mediterranean fever gene (MEFV) mutation, i.e. heterozygous E148Q. They also shared HLA-A24, -DR15 alleles. Simultaneous occurrence of MEFV mutation and HLA alleles with CPAN has never been reported in Japan. These cases could provide some hereditary clue for the development of CPAN.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Poliarterite Nodosa
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Dermatopatias Vasculares
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Tela Subcutânea
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Antígeno HLA-A24
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Pirina
Tipo de estudo:
Diagnostic_studies
Limite:
Child
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Female
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Humans
País/Região como assunto:
Asia
Idioma:
En
Revista:
Mod Rheumatol
Ano de publicação:
2018
Tipo de documento:
Article