Bisphosphonate related osteonecrosis of calvarial bone.

BACKGROUND: A case of bisphosphonate related osteonecrosis of calvarial bone has not been reported. METHODS: The clinical, imaging, and histopathological findings of the patient are presented. A 72-year-old female treated with bisphosphonates for osteoporosis presented with an open wound of her scalp. CT, MRI and bone scan suggested lytic and sclerotic changes with inflammation. RESULTS: Surgical debridement was performed and final pathology was consistent with osteonecrosis and osteomyelitis. CONCLUSIONS: This case illustrates that bisphosphonates can induce osteonecrosis of calvarial bone.