Budesonide, but not dexamethasone, blunted the response of aldosterone to renin elevation by suppressing angiotensin converting enzyme upon high-altitude exposure.
J Renin Angiotensin Aldosterone Syst
; 17(2): 1470320316653867, 2016.
Article
em En
| MEDLINE
| ID: mdl-27317302
ABSTRACT
INTRODUCTION:
Inhaled budesonide is a novel approach to prevent acute mountain sickness (AMS). However, its mechanism is not completely understood. We aimed to investigate the effects of budesonide and dexamethasone on renin-angiotensin-aldosterone system in AMS prevention. MATERIALS ANDMETHODS:
Data were obtained from a randomised controlled trial including 138 participants. The participants were randomly assigned to receive budesonide, dexamethasone or placebo as prophylaxis before they travelled to 3450 m altitude from 400 m by car. Their plasma concentrations of renin, angiotensin-converting enzyme (ACE) and aldosterone were measured at both altitudes.RESULTS:
All parameters were comparable among the three groups at 400 m. After high-altitude exposure of 3450, renin in all groups increased significantly; the ACE, aldosterone concentrations, as well as the aldosterone/renin ratio, rose markedly in the dexamethasone and placebo groups but not in the budesonide group. Moreover, the aldosterone/renin ratio correlated closely with ACE concentration.CONCLUSIONS:
Upon acute high-altitude exposure, budesonide, but not dexamethasone, blunted the response of aldosterone to renin elevation by suppressing angiotensin converting enzyme.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dexametasona
/
Renina
/
Peptidil Dipeptidase A
/
Budesonida
/
Aldosterona
/
Doença da Altitude
Tipo de estudo:
Clinical_trials
Limite:
Humans
Idioma:
En
Revista:
J Renin Angiotensin Aldosterone Syst
Ano de publicação:
2016
Tipo de documento:
Article