Phosphoinositide signaling in sperm development.
Semin Cell Dev Biol
; 59: 2-9, 2016 11.
Article
em En
| MEDLINE
| ID: mdl-27321976
ABSTRACT
Phosphatidylinositol phosphates (PIPs)1 are membrane lipids with crucial roles during cell morphogenesis, including the establishment of cytoskeletal organization, membrane trafficking, cell polarity, cell-cycle control and signaling. Recent studies in mice (Mus musculus), fruit flies (Drosophila melanogaster) and other organisms have defined germ cell intrinsic requirements for these lipids and their regulatory enzymes in multiple aspects of sperm development. In particular, PIP levels are crucial in germline stem cell maintenance, spermatogonial proliferation and survival, spermatocyte cytokinesis, spermatid polarization, sperm tail formation, nuclear shaping, and production of mature, motile sperm. Here, we briefly review the stages of spermatogenesis and discuss the roles of PIPs and their regulatory enzymes in male germ cell development.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fosfatidilinositóis
/
Espermatozoides
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Transdução de Sinais
Limite:
Animals
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Humans
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Male
Idioma:
En
Revista:
Semin Cell Dev Biol
Ano de publicação:
2016
Tipo de documento:
Article