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Histamine in diabetes: Is it time to reconsider?
Pini, Alessandro; Obara, Ilona; Battell, Emma; Chazot, Paul L; Rosa, Arianna Carolina.
Afiliação
  • Pini A; Department of Clinical and Experimental Medicine, University of Florence, Viale Pieraccini 6, 50139, Florence, Italy. Electronic address: apini@unifi.it.
  • Obara I; School of Medicine, Pharmacy and Health, Durham University, Stockton-on-Tees TS17 6BH, United Kingdom. Electronic address: ilona.obara@durham.ac.uk.
  • Battell E; School of Biological and Biomedical Science, Durham University, Durham DH13LE, United Kingdom. Electronic address: emma.battell@durham.ac.uk.
  • Chazot PL; School of Biological and Biomedical Science, Durham University, Durham DH13LE, United Kingdom. Electronic address: paul.chazot@durham.ac.uk.
  • Rosa AC; School of Biological and Biomedical Science, Durham University, Durham DH13LE, United Kingdom; Department of Scienza e Tecnologia del Farmaco, University of Turin, Via P. Giuria 9, 10125, Turin, Italy. Electronic address: acrosa@unito.it.
Pharmacol Res ; 111: 316-324, 2016 09.
Article em En | MEDLINE | ID: mdl-27343700
The first studies of histamine and diabetes date back to the 1950s. Since that time the involvement of histamine in diabetes was related to its well known vasoactive properties and permeability leakage effects. In particular, the first evidence for a correlation between histamine and diabetes arose in 1989 when an increase in plasma and leucocyte histamine content was observed. Limited independent evidence followed in the subsequent two decades, focusing on both histamine glyceamic control and macro- and microvascular complications of diabetes. However, recent observations have sparked the question whether it is time to reconsider the functional contribution of histamine in diabetes. We reveal an interesting upsurge in the field which provides scope for new insights into the role of histamine in diabetes.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glicemia / Histamina / Complicações do Diabetes / Diabetes Mellitus Limite: Animals / Humans Idioma: En Revista: Pharmacol Res Ano de publicação: 2016 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glicemia / Histamina / Complicações do Diabetes / Diabetes Mellitus Limite: Animals / Humans Idioma: En Revista: Pharmacol Res Ano de publicação: 2016 Tipo de documento: Article