Scaffold-hopping of bioactive flavonoids: Discovery of aryl-pyridopyrimidinones as potent anticancer agents that inhibit catalytic role of topoisomerase II&#945;.

Priyadarshani, Garima; Amrutkar, Suyog; Nayak, Anmada; Banerjee, Uttam C; Kundu, Chanakya N; Guchhait, Sankar K

Scaffold-hopping of bioactive flavonoids: Discovery of aryl-pyridopyrimidinones as potent anticancer agents that inhibit catalytic role of topoisomerase IIα.

Priyadarshani, Garima; Amrutkar, Suyog; Nayak, Anmada; Banerjee, Uttam C; Kundu, Chanakya N; Guchhait, Sankar K.

Afiliação

Priyadarshani G; Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, SAS Nagar, Mohali, Punjab 160062, India.
Amrutkar S; Department of Pharmaceutical Technology (Biotechnology), National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, SAS Nagar, Mohali, Punjab 160062, India.
Nayak A; School of Biotechnology, KIIT University, Campus-11, Patia, Bhubaneswar, Orissa 751024, India.
Banerjee UC; Department of Pharmaceutical Technology (Biotechnology), National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, SAS Nagar, Mohali, Punjab 160062, India.
Kundu CN; School of Biotechnology, KIIT University, Campus-11, Patia, Bhubaneswar, Orissa 751024, India.
Guchhait SK; Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, SAS Nagar, Mohali, Punjab 160062, India. Electronic address: skguchhait@niper.ac.in.

Eur J Med Chem ; 122: 43-54, 2016 Oct 21.

Article em En | MEDLINE | ID: mdl-27343852

Assuntos

Proteínas de Ligação a DNA/antagonistas & inibidores; Desenho de Fármacos; Flavonoides/química; Flavonoides/farmacologia; Pirimidinonas/química; Antígenos de Neoplasias; Antineoplásicos/química; Antineoplásicos/farmacologia; Apoptose/efeitos dos fármacos; Linhagem Celular Tumoral; DNA Topoisomerases Tipo II; Humanos; Invasividade Neoplásica; Inibidores da Topoisomerase II/química; Inibidores da Topoisomerase II/farmacologia

Palavras-chave

Anticancer agent; Drug discovery; Flavonoids; Human topoisomerase IIα; Pyrido[1,2-a]pyrimidin-4-ones; Scaffold-hopping

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirimidinonas / Flavonoides / Desenho de Fármacos / Proteínas de Ligação a DNA Limite: Humans Idioma: En Revista: Eur J Med Chem Ano de publicação: 2016 Tipo de documento: Article

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