[Preparation of diagnostic antitoxic serum to Clostridium difficile]. / Poluchenie diagnosticheskoi antitoksicheskoi syvorotki k Clostridium difficile.
Zh Mikrobiol Epidemiol Immunobiol
; (4): 22-4, 1989 Apr.
Article
em Ru
| MEDLINE
| ID: mdl-2735166
ABSTRACT
The results of the studies on the preparation of diagnostic antitoxic sera to C. difficile, intended for use in biological assays with the aim of the laboratory diagnosis of clostridial enteric infections, are presented. The conditions for the detoxification of C. difficile native toxin have been established, the optimum schedules for the immunization of rabbits have been selected and specific antitoxic sera to C. difficile have been obtained. The neutralizing activity of these sera has been evaluated in the lethality test and in the cytotoxic test on human embryo dermo-muscular fibroblast cells M-19.
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Coleções:
01-internacional
Contexto em Saúde:
3_ND
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Bactérias
/
Toxinas Bacterianas
/
Antitoxinas
/
Infecções por Clostridium
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
Idioma:
Ru
Revista:
Zh Mikrobiol Epidemiol Immunobiol
Ano de publicação:
1989
Tipo de documento:
Article