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Protection of Humanized Mice From Repeated Intravaginal HIV Challenge by Passive Immunization: A Model for Studying the Efficacy of Neutralizing Antibodies In Vivo.
Deruaz, Maud; Moldt, Brian; Le, Khoa M; Power, Karen A; Vrbanac, Vladimir D; Tanno, Serah; Ghebremichael, Musie S; Allen, Todd M; Tager, Andrew M; Burton, Dennis R; Luster, Andrew D.
Afiliação
  • Deruaz M; Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston.
  • Moldt B; Department of Immunology and Microbial Science, Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, and IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, California.
  • Le KM; Department of Immunology and Microbial Science, Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, and IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, California.
  • Power KA; Ragon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts.
  • Vrbanac VD; Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston Ragon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts.
  • Tanno S; Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston Ragon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts.
  • Ghebremichael MS; Ragon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts.
  • Allen TM; Ragon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts.
  • Tager AM; Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston Ragon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts.
  • Burton DR; Ragon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts Department of Immunology and Microbial Science, Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, and IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, California.
  • Luster AD; Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston.
J Infect Dis ; 214(4): 612-6, 2016 08 15.
Article em En | MEDLINE | ID: mdl-27357340
ABSTRACT
Humanized mice reconstituted with a human immune system can be mucosally infected with human immunodeficiency virus (HIV), opening up the possibility of studying HIV transmission in a small-animal model. Here we report that passive immunization with the broadly neutralizing antibody b12 protected humanized mice against repetitive intravaginal infection in a dose-dependent manner. In addition, treatment with the antibody PGT126, which is more potent in vitro, was more efficacious in vivo and provided sterilizing protection. Our results demonstrate that humanized mice can be used as a small-animal model to study the efficacy and mechanism of broadly neutralizing antibody protection against HIV acquisition.
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 2_ODS3 Base de dados: MEDLINE Assunto principal: Anticorpos Anti-HIV / Infecções por HIV / Imunização Passiva / Modelos Animais de Doenças / Anticorpos Neutralizantes Limite: Animals Idioma: En Revista: J Infect Dis Ano de publicação: 2016 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 2_ODS3 Base de dados: MEDLINE Assunto principal: Anticorpos Anti-HIV / Infecções por HIV / Imunização Passiva / Modelos Animais de Doenças / Anticorpos Neutralizantes Limite: Animals Idioma: En Revista: J Infect Dis Ano de publicação: 2016 Tipo de documento: Article