Increased expression of the histone H3 lysine 4 methyltransferase MLL4 and the histone H3 lysine 27 demethylase UTX prolonging the overall survival of patients with glioblastoma and a methylated MGMT promoter.

Kim, Jinho; Lee, Sung-Hun; Jang, Ji Hwan; Kim, Mee-Seon; Lee, Eun Hee; Kim, Young Zoon

Kim, Jinho; Lee, Sung-Hun; Jang, Ji Hwan; Kim, Mee-Seon; Lee, Eun Hee; Kim, Young Zoon.

Afiliação

Kim J; Department of Neurosurgery, Division of Neurooncology, and.
Lee SH; Department of Molecular and Cellular Oncology, Center for Cancer Epigenetics, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Jang JH; Department of Neurosurgery, Division of Neurooncology, and.
Kim MS; Department of Pathology, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Republic of Korea; and.
Lee EH; Department of Pathology, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Republic of Korea; and.
Kim YZ; Department of Neurosurgery, Division of Neurooncology, and.

J Neurosurg ; 126(5): 1461-1471, 2017 05.

Article em En | MEDLINE | ID: mdl-27367247

Assuntos

Neoplasias Encefálicas; Neoplasias da Mama; Glioblastoma; Antineoplásicos Alquilantes; Proliferação de Células; Metilação de DNA; Metilases de Modificação do DNA/genética; Enzimas Reparadoras do DNA/genética; Proteínas de Ligação a DNA; Histona Desmetilases; Histona-Lisina N-Metiltransferase; Histonas; Humanos; Lisina; Metiltransferases; Proteínas Nucleares; Prognóstico; Estudos Retrospectivos; Proteínas Supressoras de Tumor/genética

Palavras-chave

CpG = cytosine-phosphate-guanine; FFPE = formalin-fixed, paraffin-embedded; GBM = glioblastoma; MGMT = O-6-methylguanine DNA methyltransferase; MLL4 = mixed lineage leukemia 4; MSP = methylation-specific PCR; O-6-methyl guanine methyltransferase; OS = overall survival; PFS = progression-free survival; PSQ = pyrosequencing; ROC = receiver operating characteristic; RPA = recursive partitioning analysis; UTX = ubiquitously transcribed tetratricopeptide repeat gene on X chromosome; UTXMLL4 complex; epigenome; glioblastoma; oncology; prognosis; survival

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Neoplasias da Mama / Glioblastoma Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: J Neurosurg Ano de publicação: 2017 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google