Clinical Relevance and Mechanisms of Antagonism Between the BMP and Activin/TGF-ß Signaling Pathways.
J Am Osteopath Assoc
; 116(7): 452-61, 2016 Jul 01.
Article
em En
| MEDLINE
| ID: mdl-27367950
ABSTRACT
The transforming growth factor ß (TGF-ß) superfamily is a large group of signaling molecules that participate in embryogenesis, organogenesis, and tissue homeostasis. These molecules are present in all animal genomes. Dysfunction in the regulation or activity of this superfamily's components underlies numerous human diseases and developmental defects. There are 2 distinct arms downstream of the TGF-ß superfamily ligands-the bone morphogenetic protein (BMP) and activin/TGF-ß signaling pathways-and these 2 responses can oppose one another's effects, most notably in disease states. However, studies have commonly focused on a single arm of the TGF-ß superfamily, and the antagonism between these pathways is unknown in most physiologic and pathologic contexts. In this review, the authors summarize the clinically relevant scenarios in which the BMP and activin/TGF-ß pathways reportedly oppose one another and identify several molecular mechanisms proposed to mediate this interaction. Particular attention is paid to experimental findings that may be informative to human pathology to highlight potential therapeutic approaches for future investigation.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fator de Crescimento Transformador beta
/
Proteínas Morfogenéticas Ósseas
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
J Am Osteopath Assoc
Ano de publicação:
2016
Tipo de documento:
Article