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Genomic analysis of the evolutionary lineage of Norovirus GII.4 from archival specimens during 1975-1987 in Tokyo.
Mori, Kohji; Chu, Pei-Yu; Motomura, Kazushi; Somura, Yoshiko; Nagano, Miyuki; Kimoto, Kana; Akiba, Tetsuya; Kai, Akemi; Sadamasu, Kenji.
Afiliação
  • Mori K; Department of Microbiology, Tokyo Metropolitan Institute of Public Health, Tokyo, Japan.
  • Chu PY; Department of Medical Laboratory Science and Biotechnology, Kaohsiung Medical University, Kaohsiung, Taiwan.
  • Motomura K; Research Institute of Microbial Diseases, Osaka University, Suita, Osaka, Japan.
  • Somura Y; Department of Microbiology, Tokyo Metropolitan Institute of Public Health, Tokyo, Japan.
  • Nagano M; Department of Microbiology, Tokyo Metropolitan Institute of Public Health, Tokyo, Japan.
  • Kimoto K; Department of Microbiology, Tokyo Metropolitan Institute of Public Health, Tokyo, Japan.
  • Akiba T; Department of Microbiology, Tokyo Metropolitan Institute of Public Health, Tokyo, Japan.
  • Kai A; Department of Microbiology, Tokyo Metropolitan Institute of Public Health, Tokyo, Japan.
  • Sadamasu K; Department of Microbiology, Tokyo Metropolitan Institute of Public Health, Tokyo, Japan.
J Med Virol ; 89(2): 363-367, 2017 02.
Article em En | MEDLINE | ID: mdl-27380721
ABSTRACT
This study aimed to analyze NoV GII.4 sequences from archival specimens obtained during 1975-1987 by comparing them with reference sequences. The first NoV GII.P4_GII.4 sequence was identified in 1980. NoV GII.4 collected in 1970 had a GII.P1_GII.4 sequence. These results indicate that the GII.P4_GII.4 sequence may be the result of a recombination that might have occurred around 1980. Amino acid substitutions based on this replacement were mainly accumulated in the NTPase, p22, and RdRp regions. The emergence of GII.P4_GII.4 sequence is considered to have ended the major prevalence of NoV GII.4. J. Med. Virol. 89363-367, 2017. © 2016 Wiley Periodicals, Inc.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Análise de Sequência de DNA / Infecções por Caliciviridae / Norovirus / Genótipo Tipo de estudo: Risk_factors_studies Limite: Humans País/Região como assunto: Asia Idioma: En Revista: J Med Virol Ano de publicação: 2017 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Análise de Sequência de DNA / Infecções por Caliciviridae / Norovirus / Genótipo Tipo de estudo: Risk_factors_studies Limite: Humans País/Região como assunto: Asia Idioma: En Revista: J Med Virol Ano de publicação: 2017 Tipo de documento: Article