Phenotypic and genetic heterogeneity of tumor tissue and circulating tumor cells in patients with metastatic castration-resistant prostate cancer: A report from the PETRUS prospective study.

Massard, Christophe; Oulhen, Marianne; Le Moulec, Sylvestre; Auger, Nathalie; Foulon, Stéphanie; Abou-Lovergne, Aurélie; Billiot, Fanny; Valent, Alexander; Marty, Virginie; Loriot, Yohann; Fizazi, Karim; Vielh, Philippe; Farace, Francoise

Massard, Christophe; Oulhen, Marianne; Le Moulec, Sylvestre; Auger, Nathalie; Foulon, Stéphanie; Abou-Lovergne, Aurélie; Billiot, Fanny; Valent, Alexander; Marty, Virginie; Loriot, Yohann; Fizazi, Karim; Vielh, Philippe; Farace, Francoise.

Afiliação

Massard C; Gustave Roussy, Université Paris-Saclay, Department of Medicine, F-94805, Villejuif, France.
Oulhen M; INSERM, U981 "Identification of Molecular Predictors and New Targets for Cancer Treatment", F-94805, Villejuif, France.
Le Moulec S; INSERM, U981 "Identification of Molecular Predictors and New Targets for Cancer Treatment", F-94805, Villejuif, France.
Auger N; Gustave Roussy, Université Paris-Saclay, "Circulating Tumor Cells" Translational Platform, AMMICA CNRS UMS3655 - INSERM US23, F-94805, Villejuif, France.
Foulon S; Hôpital d'Instruction des Armées du Val de Grâce, Department of Oncology, F-75005, Paris, France.
Abou-Lovergne A; Gustave Roussy, Université Paris-Saclay, Department of Biopathology, F-94805, Villejuif, France.
Billiot F; Gustave Roussy, Université Paris-Saclay, Department of Biostatistics and Epidemiology, F-94805, Villejuif, France.
Valent A; Gustave Roussy, Université Paris-Saclay, Department of Medicine, F-94805, Villejuif, France.
Marty V; INSERM, U981 "Identification of Molecular Predictors and New Targets for Cancer Treatment", F-94805, Villejuif, France.
Loriot Y; Gustave Roussy, Université Paris-Saclay, "Circulating Tumor Cells" Translational Platform, AMMICA CNRS UMS3655 - INSERM US23, F-94805, Villejuif, France.
Fizazi K; Gustave Roussy, Université Paris-Saclay, Department of Biopathology, F-94805, Villejuif, France.
Vielh P; Gustave Roussy, Université Paris-Saclay, "Histo Cytopathology" Translational Platform, AMMICA CNRS UMS3655 - INSERM US23, F-94805, Villejuif, France.
Farace F; Gustave Roussy, Université Paris-Saclay, Department of Medicine, F-94805, Villejuif, France.

Oncotarget ; 7(34): 55069-55082, 2016 08 23.

Article em En | MEDLINE | ID: mdl-27391263

Assuntos

Heterogeneidade Genética; Células Neoplásicas Circulantes/metabolismo; Próstata/metabolismo; Neoplasias de Próstata Resistentes à Castração/genética; Idoso; Idoso de 80 Anos ou mais; Biomarcadores Tumorais/genética; Biomarcadores Tumorais/metabolismo; Biópsia; Humanos; Masculino; Pessoa de Meia-Idade; Metástase Neoplásica; Proteínas de Fusão Oncogênica/genética; Proteínas de Fusão Oncogênica/metabolismo; Fenótipo; Estudos Prospectivos; Próstata/efeitos dos fármacos; Próstata/patologia; Neoplasias de Próstata Resistentes à Castração/tratamento farmacológico; Neoplasias de Próstata Resistentes à Castração/patologia; Receptores Androgênicos/genética; Receptores Androgênicos/metabolismo; Relatório de Pesquisa

Palavras-chave

TMPRSS2-ERG translocation; androgen receptor; biopsy; circulating tumor cells; prostate cancer

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Próstata / Heterogeneidade Genética / Neoplasias de Próstata Resistentes à Castração / Células Neoplásicas Circulantes Tipo de estudo: Clinical_trials / Observational_studies Limite: Aged / Aged80 / Humans / Male / Middle aged Idioma: En Revista: Oncotarget Ano de publicação: 2016 Tipo de documento: Article

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