Facial manifestations of Epstein-Barr virus-related lymphoproliferative disease in childhood acute lymphoblastic leukemia in remission: Two atypical presentations.
Pediatr Blood Cancer
; 63(11): 2042-5, 2016 11.
Article
em En
| MEDLINE
| ID: mdl-27392033
ABSTRACT
Epstein-Barr virus-related lymphoproliferative disease (EBV-LPD) rarely occurs in patients with acute lymphoblastic leukemia (ALL), who have not received hematopoietic transplantation. We describe EBV-LPD manifesting as facial lesions in two children with ALL in remission. One patient was a 16-year-old male with T-cell ALL with an EBV-positive angiocentric polymorphous lip lesion presenting as right-sided facial swelling. The other patient was a 12-year-old male with B-cell ALL with an EBV-positive polymorphous lymphoplasmacytic infiltrate presenting as bilateral dacryoadenitis. Neither patient had known primary immunodeficiencies. Both cases improved with immunosuppressant de-escalation. These cases suggest that immunosuppression induced by maintenance chemotherapy is sufficient to promote EBV-LPD.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Infecções por Vírus Epstein-Barr
/
Dacriocistite
/
Leucemia-Linfoma Linfoblástico de Células Precursoras
/
Transtornos Linfoproliferativos
Limite:
Adolescent
/
Child
/
Humans
/
Male
Idioma:
En
Revista:
Pediatr Blood Cancer
Ano de publicação:
2016
Tipo de documento:
Article