Application of the Protein Maker as a platform purification system for therapeutic antibody research and development.

Hélie, Geneviève; Parat, Marie; Massé, Frédéric; Gerdts, Cory J; Loisel, Thomas P; Matte, Allan

Hélie, Geneviève; Parat, Marie; Massé, Frédéric; Gerdts, Cory J; Loisel, Thomas P; Matte, Allan.

Afiliação

Hélie G; Protein Purification, Human Health Therapeutics, National Research Council Canada, 6100 Royalmount Ave. Montreal, QC H4P 2R2, Canada.
Parat M; Protein Purification, Human Health Therapeutics, National Research Council Canada, 6100 Royalmount Ave. Montreal, QC H4P 2R2, Canada.
Massé F; Primary Assays, Human Health Therapeutics, National Research Council Canada, 6100 Royalmount Ave. Montreal, QC H4P 2R2, Canada.
Gerdts CJ; Protein BioSolutions Inc., Suite 280, 401 Professional Drive, Gaithersburg, MD, 20879, USA.
Loisel TP; Protein Purification, Human Health Therapeutics, National Research Council Canada, 6100 Royalmount Ave. Montreal, QC H4P 2R2, Canada.
Matte A; Protein Purification, Human Health Therapeutics, National Research Council Canada, 6100 Royalmount Ave. Montreal, QC H4P 2R2, Canada.

Comput Struct Biotechnol J ; 14: 238-44, 2016.

Article em En | MEDLINE | ID: mdl-27418955

Palavras-chave

Antibody; CHO, Chinese Hamster Ovary; DPBS, Dulbecco's phosphate buffered saline; HC, IgG heavy chain; HCP, host cell protein; Hybridoma; IMAC, immobilized metal ion affinity chromatography; LC, IgG light chain; OAA, one-armed antibody; Parallelized protein purification; Process development; Protein A; Protein G; mAb, monoclonal antibody

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Comput Struct Biotechnol J Ano de publicação: 2016 Tipo de documento: Article

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PubMed Links

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Comput Struct Biotechnol J Ano de publicação: 2016 Tipo de documento: Article