Design, synthesis and biological evaluation of 5-benzylidene-2-iminothiazolidin-4-ones as selective GSK-3ß inhibitors.

Arfeen, Minhajul; Bhagat, Shweta; Patel, Rahul; Prasad, Shivcharan; Roy, Ipsita; Chakraborti, Asit K; Bharatam, Prasad V

Arfeen, Minhajul; Bhagat, Shweta; Patel, Rahul; Prasad, Shivcharan; Roy, Ipsita; Chakraborti, Asit K; Bharatam, Prasad V.

Afiliação

Arfeen M; Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Sector 67, S.A.S. Nagar, 160062, Punjab, India.
Bhagat S; Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Sector 67, S.A.S. Nagar, 160062, Punjab, India.
Patel R; Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Sector 67, S.A.S. Nagar, 160062, Punjab, India.
Prasad S; Department of Biotechnology, National Institute of Pharmaceutical Education and Research, Sector 67, S.A.S. Nagar, 160062, Punjab, India.
Roy I; Department of Biotechnology, National Institute of Pharmaceutical Education and Research, Sector 67, S.A.S. Nagar, 160062, Punjab, India.
Chakraborti AK; Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Sector 67, S.A.S. Nagar, 160062, Punjab, India.
Bharatam PV; Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Sector 67, S.A.S. Nagar, 160062, Punjab, India. Electronic address: pvbharatam@niper.ac.in.

Eur J Med Chem ; 121: 727-736, 2016 Oct 04.

Article em En | MEDLINE | ID: mdl-27423119

Assuntos

Desenho de Fármacos; Glicogênio Sintase Quinase 3 beta/antagonistas & inibidores; Inibidores de Proteínas Quinases/síntese química; Inibidores de Proteínas Quinases/farmacologia; Tiazolidinas/síntese química; Tiazolidinas/farmacologia; Trifosfato de Adenosina/metabolismo; Ligação Competitiva; Técnicas de Química Sintética; Glicogênio Sintase Quinase 3 beta/química; Glicogênio Sintase Quinase 3 beta/metabolismo; Humanos; Simulação de Acoplamento Molecular; Simulação de Dinâmica Molecular; Conformação Proteica; Inibidores de Proteínas Quinases/química; Inibidores de Proteínas Quinases/metabolismo; Relação Estrutura-Atividade; Tiazolidinas/química; Tiazolidinas/metabolismo

Palavras-chave

CDK-2; GSK-3; Molecular docking; Molecular dynamics; SBDD

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Desenho de Fármacos / Inibidores de Proteínas Quinases / Tiazolidinas / Glicogênio Sintase Quinase 3 beta Limite: Humans Idioma: En Revista: Eur J Med Chem Ano de publicação: 2016 Tipo de documento: Article

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