Functional foldamers that target bacterial membranes: The effect of charge, amphiphilicity and conformation.
Bioorg Med Chem
; 24(18): 4241-4245, 2016 09 15.
Article
em En
| MEDLINE
| ID: mdl-27427397
ABSTRACT
By varying the molecular charge, shape and amphiphilicity of a series of conformationally distinct diarylureas it is possible to control the levels of phospholipid membrane lysis using membranes composed of bacterial lipid extracts. From the data obtained, it appears as though the lysis activity observed is not due to charge, conformation or amphiphilicity in isolation, but that surface aggregation, H-bonding and other factors may also play a part. The work provides evidence that this class of foldamer possesses potential for optimisation into new antibacterial agents.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
3_ND
Base de dados:
MEDLINE
Assunto principal:
Compostos de Fenilureia
/
Tensoativos
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Membrana Celular
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Compostos de Metilureia
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Antibacterianos
Idioma:
En
Revista:
Bioorg Med Chem
Ano de publicação:
2016
Tipo de documento:
Article