Diabetes converts arterial regulation by perivascular adipose tissue from relaxation into H(2)O(2)-mediated contraction.
Physiol Res
; 65(5): 799-807, 2016 11 23.
Article
em En
| MEDLINE
| ID: mdl-27429118
ABSTRACT
This study aims to reveal the reason for the increased force of 5-hydroxytryptamine-induced contraction of endothelium-denuded skeletal muscle arteries of diabetic rats in the presence of perivascular adipose tissue (PVAT). Our data on rat gracilis arteries show that i) PVAT of skeletal muscle arteries of healthy and diabetic rats releases hydrogen peroxide (H(2)O(2)), ii) higher concentrations of 5-hydroxytryptamine increase the production of H(2)O(2) in PVAT; iii) an enhanced PVAT production of H(2)O(2) is the main, if not the only, reason for the sensitization of arterial contraction to 5-hydroxytriptamine-induced contraction in diabetes and iv) endothelium antagonizes the effect of PVAT-derived H(2)O(2).
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Artérias
/
Vasoconstrição
/
Tecido Adiposo
/
Diabetes Mellitus Experimental
/
Peróxido de Hidrogênio
Limite:
Animals
Idioma:
En
Revista:
Physiol Res
Ano de publicação:
2016
Tipo de documento:
Article