Transient global ventricular dysfunction in an adolescent affected by pancreatic adenocarcinoma.
BMC Pediatr
; 16: 99, 2016 07 19.
Article
em En
| MEDLINE
| ID: mdl-27435703
ABSTRACT
BACKGROUND:
Takotsubo cardiomyopathy (TC) is characterized by a transient decrease in ejection fraction and a reversible left ventricular dysfunction. The pathophysiology of TC is not completely understood. Heterogeneous and multifactorial mechanisms are involved drugs, emotional and physical stress, genetic and hormonal factors. CASE PRESENTATION A 17 year-old male with metastatic pancreatic adenocarcinoma, under chemotherapy containing 5-fluorouracil, presented severe left ventricular dysfunction requiring mechanical ventilation and inotropes administration. He completely recovered in 2 weeks.CONCLUSION:
To our knowledge this is the first report of transient form of ventricular dysfunction, mimicking TC, in an adolescent. We believe that children and adolescents receiving 5-fluorouracil should be closely monitored and referred for investigation if they develop cardiac symptoms.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Pancreáticas
/
Adenocarcinoma
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Cardiomiopatia de Takotsubo
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Fluoruracila
/
Antimetabólitos Antineoplásicos
Tipo de estudo:
Diagnostic_studies
Limite:
Adolescent
/
Humans
/
Male
Idioma:
En
Revista:
BMC Pediatr
Ano de publicação:
2016
Tipo de documento:
Article