Cardiovascular risk of BRCA1/2 mutation carriers: A review.
Maturitas
; 91: 135-9, 2016 Sep.
Article
em En
| MEDLINE
| ID: mdl-27451331
ABSTRACT
BRCA1/2 mutation carriers are at high risk of breast and ovarian cancer. The number of studies on non-cancer endpoints in BRCA1/2 mutation carriers is still limited. BRCA1/2 mutation carriers may be at higher cardiovascular risk due to early menopause after risk-reducing salpingo-oophorectomy and/or due to the potential cardiotoxic effects of breast cancer treatment (radiotherapy and chemotherapy). Moreover, BRCA genes have a role as a gatekeeper in cardiac function and structure, which may affect susceptibility to cardiac damage. Our goal is to review current knowledge of cardiovascular risk among BRCA1/2 mutation carriers.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
2_ODS3
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
/
Doenças Cardiovasculares
/
Proteína BRCA1
/
Predisposição Genética para Doença
/
Proteína BRCA2
Tipo de estudo:
Etiology_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
Idioma:
En
Revista:
Maturitas
Ano de publicação:
2016
Tipo de documento:
Article