Synthesis, characterization and in vitro evaluation of substituted N-(2-phenylcyclopropyl)carbamates as acetyl- and butyrylcholinesterase inhibitors.

Horáková, Eva; Drabina, Pavel; Broz, Bretislav; Stepánková, Sárka; Vorcáková, Katarína; Královec, Karel; Havelek, Radim; Sedlák, Milos

Horáková, Eva; Drabina, Pavel; Broz, Bretislav; Stepánková, Sárka; Vorcáková, Katarína; Královec, Karel; Havelek, Radim; Sedlák, Milos.

Afiliação

Horáková E; a Institute of Organic Chemistry and Technology, Faculty of Chemical Technology, University of Pardubice , Pardubice , Czech Republic and.
Drabina P; a Institute of Organic Chemistry and Technology, Faculty of Chemical Technology, University of Pardubice , Pardubice , Czech Republic and.
Broz B; a Institute of Organic Chemistry and Technology, Faculty of Chemical Technology, University of Pardubice , Pardubice , Czech Republic and.
Stepánková S; b Department of Biological and Biochemical Sciences , Faculty of Chemical Technology, University of Pardubice , Pardubice , Czech Republic.
Vorcáková K; b Department of Biological and Biochemical Sciences , Faculty of Chemical Technology, University of Pardubice , Pardubice , Czech Republic.
Královec K; b Department of Biological and Biochemical Sciences , Faculty of Chemical Technology, University of Pardubice , Pardubice , Czech Republic.
Havelek R; b Department of Biological and Biochemical Sciences , Faculty of Chemical Technology, University of Pardubice , Pardubice , Czech Republic.
Sedlák M; a Institute of Organic Chemistry and Technology, Faculty of Chemical Technology, University of Pardubice , Pardubice , Czech Republic and.

J Enzyme Inhib Med Chem ; 31(sup3): 173-179, 2016.

Article em En | MEDLINE | ID: mdl-27476673

Assuntos

Acetilcolinesterase/metabolismo; Butirilcolinesterase/metabolismo; Carbamatos/síntese química; Carbamatos/farmacologia; Inibidores da Colinesterase/síntese química; Inibidores da Colinesterase/farmacologia; Carbamatos/química; Sobrevivência Celular/efeitos dos fármacos; Inibidores da Colinesterase/química; Relação Dose-Resposta a Droga; Humanos; Células Jurkat; Estrutura Molecular; Relação Estrutura-Atividade

Palavras-chave

Carbamates; cholinesterase inhibitors; cyclopropane derivatives; in vitro cytotoxicity; lipophilicity

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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Acetilcolinesterase / Butirilcolinesterase / Carbamatos / Inibidores da Colinesterase Limite: Humans Idioma: En Revista: J Enzyme Inhib Med Chem Ano de publicação: 2016 Tipo de documento: Article

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