Analysis of allergic immune responses in humanized mice.
Cell Immunol
; 308: 7-12, 2016 10.
Article
em En
| MEDLINE
| ID: mdl-27493097
Nowadays, more than 25% of the population in industrial countries are affected by IgE-mediated (atopic) allergic diseases such as allergic rhinitis, asthma and atopic eczema. Due to intensive research on basis of in vitro studies with human immune cells and different murine in vivo models of allergy fundamental mechanisms of allergic immune responses have been elucidated during the last years. However, human studies are restricted and the immune system of mice differs from the human immune system in several aspects so that the transferability of experimental results from mice to men is limited. Humanized mice represent a new tool to analyze the interaction of human immune cells under physiological conditions as far as possible, particularly to test novel therapeutic strategies. This review summarizes the impact of humanized mouse models for the investigation and treatment of allergic diseases.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Asma
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Dessensibilização Imunológica
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Linfócitos T Reguladores
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Hipersensibilidade
Limite:
Animals
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Female
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Humans
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Male
Idioma:
En
Revista:
Cell Immunol
Ano de publicação:
2016
Tipo de documento:
Article