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Charting the chemical space around the (iso)indoline scaffold, a comprehensive approach towards multitarget directed ligands.
Éliás, Olivér; Kovács, Zoltán; Wágner, Gábor; Némethy, Zsolt; Tarcsay, Ákos; Greiner, István.
Afiliação
  • Éliás O; Gedeon Richter Plc, Budapest 10, PO Box 27, H-1475, Hungary. Electronic address: elias@richter.hu.
  • Kovács Z; Gedeon Richter Plc, Budapest 10, PO Box 27, H-1475, Hungary.
  • Wágner G; Gedeon Richter Plc, Budapest 10, PO Box 27, H-1475, Hungary.
  • Némethy Z; Gedeon Richter Plc, Budapest 10, PO Box 27, H-1475, Hungary.
  • Tarcsay Á; Gedeon Richter Plc, Budapest 10, PO Box 27, H-1475, Hungary.
  • Greiner I; Gedeon Richter Plc, Budapest 10, PO Box 27, H-1475, Hungary.
Bioorg Med Chem Lett ; 26(17): 4211-5, 2016 09 01.
Article em En | MEDLINE | ID: mdl-27496213
Within the framework of orthosteric G protein coupled receptor (GPCR) polypharmacology herein we report the systematic elaboration and thorough evaluation of a data matrix generated by sampling the chemical space around a common 5,6-fused bicyclic heteroaromatic template applying characteristic pharmacophore elements of central nervous system (CNS) relevant aminergic GPCR ligands.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Indóis / Ligantes Limite: Humans Idioma: En Revista: Bioorg Med Chem Lett Ano de publicação: 2016 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Indóis / Ligantes Limite: Humans Idioma: En Revista: Bioorg Med Chem Lett Ano de publicação: 2016 Tipo de documento: Article