Structural biology of glucan phosphatases from humans to plants.
Curr Opin Struct Biol
; 40: 62-69, 2016 10.
Article
em En
| MEDLINE
| ID: mdl-27498086
ABSTRACT
Glucan phosphatases are functionally conserved at the enzymatic level, dephosphorylating glycogen in animals and starch in plants. The human glucan phosphatase laforin is the founding member of the family and it is comprised of a carbohydrate binding module (CBM) domain followed by a dual specificity phosphatase (DSP) domain. Plants encode two glucan phosphatases Starch EXcess4 (SEX4) and Like Sex Four2 (LSF2). SEX4 contains a DSP domain followed by a CBM domain, while LSF2 contains a DSP domain and lacks a CBM. This review demonstrates how glucan phosphatase function is conserved and highlights how each family member employs a unique mechanism to bind and dephosphorylate glucan substrates.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Plantas
/
Monoéster Fosfórico Hidrolases
/
Glucanos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Opin Struct Biol
Ano de publicação:
2016
Tipo de documento:
Article