Multi-inhibitor prodrug constructs for simultaneous delivery of anti-inflammatory agents to mustard-induced skin injury.
Ann N Y Acad Sci
; 1378(1): 174-179, 2016 08.
Article
em En
| MEDLINE
| ID: mdl-27505078
ABSTRACT
The molecular pathology of sulfur mustard injury is complex, with at least nine inflammation-related enzymes and receptors upregulated in the zone of the insult. A new approach wherein inhibitors of these targets have been linked by hydrolyzable bonds, either one to one or via separate preattachment to a carrier molecule, has been shown to significantly enhance the therapeutic response compared with the individual agents. This article reviews the published work of the authors in this drug development domain over the last 8 years.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pele
/
Pró-Fármacos
/
Substâncias para a Guerra Química
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Sistemas de Liberação de Medicamentos
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Anti-Inflamatórios
/
Gás de Mostarda
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Ann N Y Acad Sci
Ano de publicação:
2016
Tipo de documento:
Article