Detection of pulmonary fat embolism with dual-energy CT: an experimental study in rabbits.
Eur Radiol
; 27(4): 1377-1385, 2017 Apr.
Article
em En
| MEDLINE
| ID: mdl-27510627
ABSTRACT
OBJECTIVES:
To evaluate the use of dual-energy CT imaging of the lung perfused blood volume (PBV) for the detection of pulmonary fat embolism (PFE).METHODS:
Dual-energy CT was performed in 24 rabbits before and 1 hour, 1 day, 4 days and 7 days after artificial induction of PFE via the right ear vein. CT pulmonary angiography (CTPA) and lung PBV images were evaluated by two radiologists, who recorded the presence, number, and location of PFE on a per-lobe basis. Sensitivity, specificity, and accuracy of CTPA and lung PBV for detecting PFE were calculated using histopathological evaluation as the reference standard.RESULTS:
A total of 144 lung lobes in 24 rabbits were evaluated and 70 fat emboli were detected on histopathological analysis. The overall sensitivity, specificity and accuracy were 25.4 %, 98.6 %, and 62.5 % for CTPA, and 82.6 %, 76.0 %, and 79.2 % for lung PBV. Higher sensitivity (p < 0.001) and accuracy (p < 0.01), but lower specificity (p < 0.001), were found for lung PBV compared with CTPA. Dual-energy CT can detect PFE earlier than CTPA (all p < 0.01).CONCLUSION:
Dual-energy CT provided higher sensitivity and accuracy in the detection of PFE as well as earlier detection compared with conventional CTPA in this animal model study. KEY POINTS ⢠Fat embolism occurs commonly in patients with traumatic bone injury. ⢠Dual-energy CT improves diagnostic performance for pulmonary fat embolism detection. ⢠Dual-energy CT can detect pulmonary fat embolism earlier than CTPA.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Embolia Pulmonar
/
Tomografia Computadorizada por Raios X
/
Embolia Gordurosa
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Eur Radiol
Ano de publicação:
2017
Tipo de documento:
Article