Systems proteomic analysis reveals that clusterin and tissue inhibitor of metalloproteinases 3 increase in leptomeningeal arteries affected by cerebral amyloid angiopathy.

Manousopoulou, A; Gatherer, M; Smith, C; Nicoll, J A R; Woelk, C H; Johnson, M; Kalaria, R; Attems, J; Garbis, S D; Carare, R O

Manousopoulou, A; Gatherer, M; Smith, C; Nicoll, J A R; Woelk, C H; Johnson, M; Kalaria, R; Attems, J; Garbis, S D; Carare, R O.

Afiliação

Manousopoulou A; Clinical and Experimental Sciences Unit, Faculty of Medicine, University of Southampton, Southampton, UK.
Gatherer M; Institute for Life Sciences, University of Southampton, Southampton, UK.
Smith C; Clinical and Experimental Sciences Unit, Faculty of Medicine, University of Southampton, Southampton, UK.
Nicoll JAR; Pathology Department, University of Edinburgh, Edinburgh, UK.
Woelk CH; Clinical and Experimental Sciences Unit, Faculty of Medicine, University of Southampton, Southampton, UK.
Johnson M; Clinical and Experimental Sciences Unit, Faculty of Medicine, University of Southampton, Southampton, UK.
Kalaria R; Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK.
Attems J; Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK.
Garbis SD; Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK.
Carare RO; Clinical and Experimental Sciences Unit, Faculty of Medicine, University of Southampton, Southampton, UK.

Neuropathol Appl Neurobiol ; 43(6): 492-504, 2017 Oct.

Article em En | MEDLINE | ID: mdl-27543695

Assuntos

Peptídeos beta-Amiloides/metabolismo; Encéfalo/irrigação sanguínea; Encéfalo/metabolismo; Angiopatia Amiloide Cerebral/metabolismo; Clusterina/metabolismo; Inibidor Tecidual de Metaloproteinase-3/metabolismo; Adulto; Idoso; Idoso de 80 Anos ou mais; Artérias/metabolismo; Encéfalo/imunologia; Encéfalo/patologia; Angiopatia Amiloide Cerebral/imunologia; Angiopatia Amiloide Cerebral/patologia; Via Clássica do Complemento; Biologia Computacional; Endofenótipos; Matriz Extracelular/metabolismo; Feminino; Humanos; Pessoa de Meia-Idade; Proteômica

Palavras-chave

TIMP3; clusterin; complement pathway; extracellular matrix remodelling; leptomeningeal arteries; proteomics

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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 6_ODS3_enfermedades_notrasmisibles Base de dados: MEDLINE Assunto principal: Encéfalo / Peptídeos beta-Amiloides / Angiopatia Amiloide Cerebral / Inibidor Tecidual de Metaloproteinase-3 / Clusterina Limite: Adult / Aged / Aged80 / Female / Humans / Middle aged Idioma: En Revista: Neuropathol Appl Neurobiol Ano de publicação: 2017 Tipo de documento: Article

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