Lentigo maligna - anatomic location as a potential risk factor for recurrences after non-surgical treatment.
J Eur Acad Dermatol Venereol
; 31(3): 450-454, 2017 Mar.
Article
em En
| MEDLINE
| ID: mdl-27557425
ABSTRACT
BACKGROUND:
A higher incidence of lentigo maligna (LM) recurrences on the nose was previously observed in our cohort after non-surgical treatment.OBJECTIVES:
To determine histological parameters that might be related to the previously observed higher incidence of LM recurrences on the nose after non-surgical treatment.METHODS:
We randomly selected 22 surgical specimens of LM on the nose and 22 on the cheek. Histopathological analysis was performed on haematoxylin and eosin stained and microphthalmia transcription factor immunohistochemically stained slides. The number of pilosebaceous units (PSU) per mm, maximum depth of atypical melanocytes along the skin appendages and maximum depth of the PSU itself were determined.RESULTS:
The nose had a significantly higher density of PSU than the cheek. The atypical melanocytes extended deeper along the PSU on the nose with a mean (SD) depth of 1.29 mm (0.48) vs. a mean depth of 0.72 mm (0.30) on the cheek (P < 0.001). The maximum depth of the PSU on the nose was greater than on the cheek, mean (SD) depth of 2.28 mm (0.41) vs. 1.65 mm (0.82) (P = 0.003).CONCLUSIONS:
The higher recurrence risk of LM on the nose after non-surgical treatment that we previously observed in our cohort is most likely based on a higher density of atypical melanocytes and also their deeper extension into the follicles. These results shed more light on our previous findings and learn that anatomical location is relevant for the risk of recurrence of LM after non-surgical treatment.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Cutâneas
/
Neoplasias Nasais
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Sarda Melanótica de Hutchinson
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Fator de Transcrição Associado à Microftalmia
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Recidiva Local de Neoplasia
Tipo de estudo:
Etiology_studies
/
Risk_factors_studies
Limite:
Aged
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Aged80
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Female
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Humans
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Male
/
Middle aged
Idioma:
En
Revista:
J Eur Acad Dermatol Venereol
Ano de publicação:
2017
Tipo de documento:
Article