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Biology of Cholangiocytes: From Bench to Bedside.
Yoo, Kyo-Sang; Lim, Woo Taek; Choi, Ho Soon.
Afiliação
  • Yoo KS; Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.
  • Lim WT; Korea University School of Medicine, Seoul, Korea.
  • Choi HS; Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.
Gut Liver ; 10(5): 687-98, 2016 Sep 15.
Article em En | MEDLINE | ID: mdl-27563020
Cholangiocytes, the lining epithelial cells in bile ducts, are an important subset of liver cells. They are activated by endogenous and exogenous stimuli and are involved in the modification of bile volume and composition. They are also involved in damaging and repairing the liver. Cholangiocytes have many functions including bile production. They are also involved in transport processes that regulate the volume and composition of bile. Cholangiocytes undergo proliferation and cell death under a variety of conditions. Cholangiocytes have functional and morphological heterogenecity. The immunobiology of cholangiocytes is important, particularly for understanding biliary disease. Secretion of different proinflammatory mediators, cytokines, and chemokines suggests the major role that cholangiocytes play in inflammatory reactions. Furthermore, paracrine secretion of growth factors and peptides mediates extensive cross-talk with other liver cells, including hepatocytes, stellate cells, stem cells, subepithelial myofibroblasts, endothelial cells, and inflammatory cells. Cholangiopathy refers to a category of chronic liver diseases whose primary disease target is the cholangiocyte. Cholangiopathy usually results in end-stage liver disease requiring liver transplant. We summarize the biology of cholangiocytes and redefine the concept of cholangiopathy. We also discuss the recent progress that has been made in understanding the pathogenesis of cholangiopathy and how such progress has influenced therapy.
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 6_ODS3_enfermedades_notrasmisibles Base de dados: MEDLINE Assunto principal: Ductos Biliares / Células Epiteliais / Fígado / Hepatopatias Limite: Humans Idioma: En Revista: Gut Liver Ano de publicação: 2016 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 6_ODS3_enfermedades_notrasmisibles Base de dados: MEDLINE Assunto principal: Ductos Biliares / Células Epiteliais / Fígado / Hepatopatias Limite: Humans Idioma: En Revista: Gut Liver Ano de publicação: 2016 Tipo de documento: Article